The Black Death, Epigenomic MERFISH, Single-Cell Long-Read Sequencing, Be Mindful of the Defaults, and more

2022-W42
natural selection
epigenomics
annotation
MAS-Seq
Author

Mikhael D. Manurung

Published

October 24, 2022

Applications

The Black Death left its mark not only on our history but also on our immunity. Luis Barreiro’s lab showed that natural selection driven by the Black Death, that were protective at that time, could be linked to present-day susceptibility to autoimmune diseases, such as Crohn’s disease.1 Great combinations of ancient DNA work, population genomics, and in-vitro infections.

Nicolet and Wolkers showed that mRNA expression levels are poorly correlated with protein abundance (Pearson r ~ 0.4).2 Interestingly, certain gene charactistics, such as untranslated region (UTR) lengths, could affect mRNA-protein correlation.